Skip to content

21c Museum Hotel St Louis

Add dates•
Secure booking Full price before payment Major cards accepted
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Image -
Thumbnail 1Thumbnail 2Thumbnail 3Thumbnail 4Thumbnail 5Thumbnail 6Thumbnail 7Thumbnail 8Thumbnail 9Thumbnail 10Thumbnail 11Thumbnail 12Thumbnail 13Thumbnail 14Thumbnail 15Thumbnail 16Thumbnail 17Thumbnail 18Thumbnail 19Thumbnail 20Thumbnail 21Thumbnail 22Thumbnail 23Thumbnail 24Thumbnail 25Thumbnail 26Thumbnail 27Thumbnail 28Thumbnail 29Thumbnail 30Thumbnail 31Thumbnail 32Thumbnail 33Thumbnail 34Thumbnail 35Thumbnail 36Thumbnail 37Thumbnail 38Thumbnail 39Thumbnail 40Thumbnail 41Thumbnail 42Thumbnail 43Thumbnail 44Thumbnail 45Thumbnail 46Thumbnail 47Thumbnail 48Thumbnail 49Thumbnail 50Thumbnail 51Thumbnail 52Thumbnail 53Thumbnail 54Thumbnail 55Thumbnail 56Thumbnail 57Thumbnail 58Thumbnail 59Thumbnail 60Thumbnail 61Thumbnail 62Thumbnail 63Thumbnail 64Thumbnail 65Thumbnail 66Thumbnail 67Thumbnail 68Thumbnail 69Thumbnail 70Thumbnail 71Thumbnail 72Thumbnail 73Thumbnail 74Thumbnail 75Thumbnail 76Thumbnail 77Thumbnail 78Thumbnail 79Thumbnail 80Thumbnail 81Thumbnail 82Thumbnail 83Thumbnail 84Thumbnail 85Thumbnail 86Thumbnail 87Thumbnail 88Thumbnail 89Thumbnail 90Thumbnail 91Thumbnail 92Thumbnail 93Thumbnail 94Thumbnail 95Thumbnail 96Thumbnail 97Thumbnail 98

Location of 21c Museum Hotel St Louis

• 1528 Locust Street
No package-only ratesSecure checkout

About 21c Museum Hotel St Louis

21c Museum Hotel reimagines a historic St. Louis fixture: the 10-story, Renaissance Revival-style YMCA building. Located in the heart of downtown St. Louis, and a short walk from the City Museum and Busch Stadium, 21c Museum Hotel St. Louis includes a 173-room boutique hotel, contemporary art museum, Idol Wolf restaurant, Good Press café, and Locust Street Athletic and Swim Club, a full-service wellness center. With more than 14, 000 square feet of exhibition and meeting & event space seamlessly integrated into all areas of the property, there are opportunities to discover contemporary art around every corner.

Room Types at 21c Museum Hotel St Louis

Available rooms & rates
1 room, 2 adults
Final taxes/fees and any local city/resort taxes are clearly shown on the next step before payment. Some local taxes are payable at the property and vary by market.

Select dates to see available rates

SUITE - (LUXURY)

Select dates to see pricing for this room

DOUBLE - (DELUXE)

Select dates to see pricing for this room

TWIN - (BUNK BED)

Select dates to see pricing for this room

DOUBLE - (DELUXE TWO QUEEN BEDS)

Select dates to see pricing for this room

DOUBLE - (LOFT)

Select dates to see pricing for this room

DOUBLE - (LUXURY)

Select dates to see pricing for this room

Room - (BUNK BED)

Select dates to see pricing for this room

SUITE - (KING SIZE BED)

Select dates to see pricing for this room

DOUBLE - (Accesible Deluxe )

Select dates to see pricing for this room

DOUBLE - (DELUXE KING BED)

Select dates to see pricing for this room

DOUBLE - (KING SIZE BED)

Select dates to see pricing for this room

SUITE - (DELUXE)

Select dates to see pricing for this room

Stayvora

We are committed to making travel seamless, affordable, and enjoyable for everyone. Discover unforgettable destinations and book with confidence.

Subscribe Newsletter

Get exclusive deals and price drop alerts straight to your inbox.

© 2026 Stayvora. All rights reserved.

Designed with care and powered by StayVora.

Registered Office: 71-75 Shelton Street, Covent Garden, London, WC2H 9JQ, United Kingdom